Menopause is a natural physiological transition defined as the end of a woman’s reproductive and childbearing ability. In the United States, the median age of menopause is approximately 51 years (1) and is associated with estrogen deficiency and significant fluctuations in various hormone synthesis and/or secretion. As a consequence of these widespread physiological and biochemical changes, menopause is associated with a variety of symptoms, including hot flashes, poor sleep quality, vaginal dryness, fatigue, and mood disturbances. 

To nutritionally support women transitioning through menopause, Isagenix has formulated a novel, multi-functional dietary supplement combining several clinically proven, patented ingredients. This supplement, Harmonia, was created to target the constellation of PMS-related symptoms.  

Meet the Ingredients of Harmonia 

EstroG-100® 

EstroG-100 is a standardized extract of three herbs used for centuries in Traditional Chinese and Korean medicine: Cynanchum wilfordii, Phlomis umbrosa, and Angelica gigas. Due to the biological properties of these herbs, EstroG-100 has been investigated as a nutritional supplement mitigating menopausal symptoms. Several clinical studies documented the benefits of EstroG-100 against menopausal symptoms and improvement in quality of life (2-5). As importantly, neither adverse effects nor alternations in estrogen or other hormones were noted in any of the studies. Interestingly, EstroG-100 has also been shown to improve measures of bone health, another major concern for women during menopause (5). 

SaffSerene™ 

SaffSerene is a standardized extract from saffron (Crocus sativus L.), the world’s most expensive spice. The standardized key bioactives in saffron are safranal, crocin, and picrocrocin. Through its effects on many biological pathways, saffron has been shown to support a healthy mood balance, mental outlook, and stress response – all of which are beneficial for menopausal symptoms (6-8).  

Probiotics 

Harmonia also features two scientifically studied probiotic strains: Lactobacillus rhamnosus GR-1® and Lactobacillus reuteri RC-14®. These probiotics support vaginal health through several properties, including: increasing healthy bacteria in the vaginal tract, reducing the growth of potentially harmful bacteria, and maintaining an optimal pH  (9-11). Moreover, these two probiotics have been studied in over 100 scientific publications. 

In summary, Harmonia features a unique and potent combination of four clinically-supported patented ingredients formulated to help support women through this natural life transition. 

References 

  1. US Preventive Services Task Force; Mangione CM, Barry MJ, Nicholson WK, Cabana M, Caughey AB, Chelmow D, Coker TR, Davis EM, Donahue KE, Jaén CR, Kubik M, Li L, Ogedegbe G, Pbert L, Ruiz JM, Stevermer J, Wong JB. Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons: US Preventive Services Task Force Recommendation Statement. JAMA. 2022 Nov 1;328(17):1740-1746. doi: 10.1001/jama.2022. 
  2. Chang A, Kwak BY, Yi K, Kim JS. The effect of herbal extract (EstroG-100) on pre-, peri- and post-menopausal women: a randomized double-blind, placebo-controlled study. Phytother Res. 2012 Apr;26(4):510-6. doi: 10.1002/ptr.3597.  
  3. Kirubamani H, Ahire P, Stalin C. Evaluation of Efficacy and Safety of EstroG-100® in Alleviating Menopausal Symptoms in Postmenopausal Women in India: A Prospective, Single-center, Single-arm, Interventional Study. J Midlife Health. 2023 Oct-Dec;14(4):285-290. doi: 10.4103/jmh.jmh_220_23.  
  4. Farzaneh F, Fallah G, Khalili-Chelik A, Fallah A, Hosseini M. Estro G-100 herbal extract and hot flashes in postmenopausal women: A randomized double-blinded controlled trial. Explore (NY). 2024 May-Jun;20(3):334-339. doi: 10.1016/j.explore.2023.09.004. 
  5. Tak K, Ryu K-J, Lee S, Lee D-J, Seo S-K. A 12-Week, Multi-Center, Double-Blind, Randomized, Placebo-Controlled Clinical Trial for the Evaluation of the Efficacy and Safety of the Herbal Extract (EstroG-100®) on Menopausal Symptoms. J Reprod Med Gynecol Obstet 2022, 7: 106. DOI: 10.24966/RMGO-2574/100106. 
  6. Hasheminasab FS, Azimi M, Raeiszadeh M. Therapeutic effects of saffron (Crocus sativus L) on female reproductive system disorders: A systematic review. Phytother Res. 2024 Jun;38(6):2832-2846. doi: 10.1002/ptr.8186.  
  7. Delam H, Keshtkaran Z, Shokrpour N, Eidi A, Bazrafshan MR. The effect of Crocus sativus L. (saffron) herbal tea on happiness in postmenopausal women: a randomized controlled trial. BMC Complement Med Ther. 2023 Jun 1;23(1):176. doi: 10.1186/s12906-023-04014-8.  
  8. Agha-Hosseini M, Kashani L, Aleyaseen A, Ghoreishi A, Rahmanpour H, Zarrinara AR, Akhondzadeh S. Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo-controlled trial. BJOG. 2008 Mar;115(4):515-9. doi: 10.1111/j.1471-0528.2007.01652.x.  
  9. Reid G, Charbonneau D, Erb J, Kochanowski B, Beuerman D, Poehner R, Bruce AW. Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women. FEMS Immunol Med Microbiol. 2003 Mar 20;35(2):131-4. doi: 10.1016/S0928-8244(02)00465-0.  
  10. Ho M, Chang YY, Chang WC, Lin HC, Wang MH, Lin WC, Chiu TH. Oral Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 to reduce Group B Streptococcus colonization in pregnant women: A randomized controlled trial. Taiwan J Obstet Gynecol. 2016 Aug;55(4):515-8. doi: 10.1016/j.tjog.2016.06.003.  
  11. Petrova MI, Lievens E, Verhoeven TL, Macklaim JM, Gloor G, Schols D, Vanderleyden J, Reid G, Lebeer S. The lectin-like protein 1 in Lactobacillus rhamnosus GR-1 mediates tissue-specific adherence to vaginal epithelium and inhibits urogenital pathogens. Sci Rep. 2016 Nov 21;6:37437. doi: 10.1038/srep37437.