What is AMPED Nitro?

AMPED™ Nitro is a multifunctional preworkout supplement formulated to maximize focus, training adaptations, and recovery.† AMPED Nitro contains a combination of ingredients including creatine monohydrate, Nitrosigine®, beta-alanine, L-citrulline, betaine, taurine, and naturally occurring caffeine from tea leaves.

What are the ingredients in AMPED Nitro, and what do they do?

Creatine monohydrate is a naturally occurring compound that helps supply energy to muscle. By increasing energy availability to muscle, creatine supports weight lifters’ efforts to lift more weight longer and sprinters’ efforts to run faster, longer. This can result in an increase in muscle mass, power, strength, and speed (1, 2). There is also evidence that creatine helps improve recovery from intense exercise (3).†

L-citrulline is a naturally occurring amino acid that increases nitric oxide production. Nitric oxide boosts athletic performance by increasing blood flow and the delivery of oxygen and nutrients to muscles during activity while also supporting cognitive performance by increasing blood flow to the brain (4). In addition to increasing the production of nitric oxide, citrulline has been shown to improve anaerobic exercise performance and stimulate muscle protein synthesis by activating muscle-building pathways (5-8).†

Nitrosigine® is a unique patented form of arginine, a metabolic precursor to nitric oxide. Nitrosigine has been shown to be more bioavailable than plain arginine alone, making it a powerful ingredient for boosting nitric oxide levels and blood flow to active muscle (9).† The benefits of Nitrosigine start in as little as 30 minutes after consuming and can last at least 3 hours. Nitrosigine has also been shown to support increases in mental acuity and focus as well as pre-workout energy levels (10, 11).†

Caffeine helps promote alertness, wakefulness, and cognitive performance. Caffeine also helps relieve fatigue, promote endurance, and improve motor performance (12). Caffeine has been shown to enhance athletic performance in various types of high-intensity exercise such as resistance training, sprinting, and team sports (13, 14).† One serving of AMPED Nitro provides 100 milligrams of naturally sourced caffeine from tea leaves, similar to the amount of caffeine provided in a 12-ounce mug of brewed coffee.

Beta-alanine is a naturally occurring amino acid that combines with histidine to form carnosine in the body. Carnosine helps create a buffer in muscle to inhibit the buildup of lactic acid, which contributes to early fatigue and exhaustion. Studies show that supplementing with beta-alanine can help extend time to fatigue and improve endurance by providing an intramuscular buffer against lactic acid accumulation (15, 16).†

Betaine is a molecule that is shuttled in and out of cells and affects cellular hydration. Supplementation with betaine has been shown to increase total repetitions and volume load while supporting increased power and force in resistance exercise (17, 18). Having increased intracellular concentrations of betaine promotes resilience to stressors (19).†

Taurine is an amino acid that has been shown to be an important factor in improving performance and protecting against oxidative stress during exercise (20). Taurine may have benefits for enhancing exercise capacity because of its cellular protective properties (21).†

Who can benefit from AMPED Nitro?

Anyone age 18 and older who is looking to improve energy, strength, and mental focus during a workout to better maximize training efforts.†

How is AMPED Nitro different from AMPED Power?

AMPED Power and AMPED Nitro both contain creatine, Nitrosigine®, and citrulline and are both effective preworkout products. AMPED Nitro also contains caffeine, beta-alanine, taurine, and betaine for those who want additional support for more effective workouts and improving performance.

Why do I feel tingling or prickly sensation when I take AMPED Nitro?

Beta-alanine, an ingredient in AMPED Nitro, may cause a mild, temporary tingling or prickly sensation in some users. This is a normal, harmless sensation and is a well-known sign that the ingredient is working. The sensation is typically felt on the face, neck, or back of the hands and should subside within 60-90 minutes after supplementation. Not everyone will feel the tingling due to individual differences and dosage sensitivity.

The temporary tingling sensation should not be confused with an allergic reaction. As with any food or dietary supplement, if you experience symptoms of an allergic reaction, please discontinue use and seek prompt medical attention.

Can pregnant and breastfeeding women use AMPED Nitro?

AMPED Nitro is not recommended for pregnant or breastfeeding women.

Should I combine AMPED Nitro with AMPED NOx and/or e+?

Depending on your goals, you may incorporate all three products – AMPED Nitro, e+™, and AMPED NOx – into your preworkout regimen.

AMPED Nitro contains 100 mg of naturally sourced caffeine from tea leaves. You should be aware of your personal level of caffeine tolerance before combining e+ with AMPED Nitro. Using AMPED Nitro and e+ together may provide more caffeine than you desire.

AMPED Power and AMPED Nitro use many of the same ingredients, so there may not be any added benefit to using the two together prior to a workout. AMPED Power is an excellent choice for those who don’t want the added caffeine or for days when you have a lighter workout planned.

AMPED NOx works to support blood flow in a different way than AMPED Nitro. It can be taken any time before a workout and can be combined with AMPED Nitro for added support.

Can I use AMPED Nitro on a Cleanse Day?

AMPED Nitro is intended for use before intense physical activity, which is not recommended on Cleanse Days. Because of this, AMPED Nitro is not recommended for Cleanse Days. For a lighter exercise regimen, you may use e+ and AMPED NOx before your workout.

Why is there sugar in AMPED Nitro?

Studies have shown that a modest intake of easily absorbed carbohydrates including simple sugars can support better exercise performance in athletes. The use of sugar also provides a pleasant flavor without the use of any artificial sweeteners or flavors.

Can AMPED Nitro be used every day?

Yes, AMPED Nitro is an effective addition to your daily exercise routine.

Is it safe to take two servings of AMPED Nitro in one day?

Many athletes perform two workouts in one day – one in the morning and one in the afternoon. For these athletes, it’s safe to use a serving of AMPED Nitro before each workout. Keep in mind that because of its inclusion of caffeine, AMPED Nitro may interfere with sleep if taken in the evening hours before bed.

Who can benefit from AMPED Nitro?

AMPED Nitro is an effective preworkout supplement for anyone participating in intense physical activity.

 

Nitrosigine is a registered trademark of Nutrition 21, LLC and is patent protected.

​​†This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

References

  1. van Loon LJ, Oosterlaar AM, Hartgens F, et al. Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humans. Clin Sci. 2003 Feb;104(2):153-62.
  2. Aguiar AF, Januário RS, Junior RP, et al. Long-term creatine supplementation improves muscular performance during resistance training in older women. Eur J Appl Physiol. 2013 Apr;113(4):987-96.
  3. Deminice R, Rosa FT, Franco GS, et al. Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans. Nutrition. 2013 Sep;29(9):1127-32.
  4. Presley TD, Morgan AR, Bechtold E, et al. Acute effect of a high nitrate diet on brain perfusion in older adults. Nitric Oxide. 2011 Jan 1;24(1):34-42.
  5. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res. 2010 May;24(5):1215-22.
  6. Cynober L, de Bandt JP, Moinard C. Leucine and citrulline: two major regulators of protein turnover. World Rev Nutr Diet. 2013; 105:97-105.
  7. Suzuki T, Morita M, Kobayashi Y, et al. Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study. J Int Soc Sports Nutr. 2016 Feb 19; 13:6.
  8. Hickner RC, Tanner CJ, Evans CA, et al. L-citrulline reduces time to exhaustion and insulin response to a graded exercise test. Med Sci Sports Exerc. 2006 Apr;38(4):660-6.
  9. Kalman DS, Feldman S, Samson A, et al. A clinical evaluation to determine the safety, pharmacokinetics and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males. Clin Pharmacol. 2015 Oct 7; 7:103-9.
  10. Kalman D, Harvey PD, Perez Ojalvo S, et al. Randomized Prospective Double-Blind Studies to Evaluate the Cognitive Effects of Inositol-Stabilized Arginine Silicate in Healthy Physically Active Adults. Nutrients. 2016 Nov 18;8(11).
  11. Rood-Ojalvo S, Sandler D, Veledar E, et al. The benefits of inositol-stabilized arginine silicate as a workout ingredient. J Int Soc Sports Nutr. 2015; 12(Suppl 1): P14.
  12. Doherty M, Smith PM. Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis. Scand J Med Sci Sports. 2005 Apr;15(2):69-78.
  13. Astorino TA, Roberson DW. Efficacy of acute caffeine ingestion for short-term high-intensity exercise performance: a systematic review. J Strength Cond Res. 2010 Jan;24(1):257-65.
  14. Smirmaul BP, de Moraes AC, Angius L, et al. Effects of caffeine on neuromuscular fatigue and performance during high-intensity cycling exercise in moderate hypoxia. Eur J Appl Physiol. 2017 Jan;117(1):27-38.
  15. Van Thienen R, Van Proeyen K, Vanden Eynde B, et al. Beta-alanine improves sprint performance in endurance cycling. Med Sci Sports Exerc. 2009 Apr;41(4):898-903.
  16. Hobson RM, Saunders B, Ball G, et al. Effects of β-alanine supplementation on exercise performance: a meta-analysis. Amino Acids. 2012 Jul;43(1):25-37.
  17. Trepanowski JF, Farney TM, McCarthy CG, et al. The effects of chronic betaine supplementation on exercise performance, skeletal muscle oxygen saturation and associated biochemical parameters in resistance trained men. J Strength Cond Res. 2011 Dec;25(12):3461-71.
  18. Hoffman JR, Ratamess NA, Kang J, et al. Effect of betaine supplementation on power performance and fatigue. J Int Soc Sports Nutr. 2009 Feb 27; 6:7.
  19. Lee EC, Maresh CM, Kraemer WJ, et al. Ergogenic effects of betaine supplementation on strength and power performance. J Int Soc Sports Nutr. 2010 Jul 19; 7:27.
  20. da Silva LA, Tromm CB, Bom KF, et al. Effects of taurine supplementation following eccentric exercise in young adults. Appl Physiol Nutr Metab. 2014 Jan;39(1):101-4.
  21. Zhang M, Izumi I, Kagamimori S, et al. Role of taurine supplementation to prevent exercise-induced oxidative stress in healthy young men. Amino Acids. 2004 Mar;26(2):203-7.